Dihexa
Memory and synapse peptide
Also known as PNB-0408, the memory peptide
- Evidence grade
- DNo completed human trialsScale
- Half-life
- Not well characterized in humans
- Schedule
- Daily, oral or subcutaneous
- Maintenance amount
- 8.00 mg
- Vial sizes sold
- 10 mg
- Cost per dose
- $206
Where a value is not established in people, this table says so rather than filling the box.
Dihexa is a synthetic angiotensin IV analog engineered for stability and brain penetration. It was developed at Washington State University and studied as a potential procognitive and anti-dementia agent.
Dihexa is thought to work by activating the hepatocyte growth factor and its c-Met receptor system, which drives formation of new synapses. This action is proposed to strengthen learning and memory circuits and to counter damage seen in neurodegeneration. Reported potency is very high at low amounts. All of this comes from laboratory work, and there are no published human trials.
There are no published human trials, so the evidence base is early research only and human safety is unestablished.
- Studied for promoting new synaptic connections tied to learning
- Explored as a potential support for memory and cognition
- Reported to be highly potent at low amounts
- Designed to reach the brain and resist rapid breakdown
- The human side-effect profile is essentially unknown, since there are no clinical trials
- Theoretical concern that HGF and c-Met activation could influence abnormal cell growth
- Possible headache or overstimulation reported anecdotally
- Purity and dosing of research-grade material vary widely
A summary of the research, not medical advice. Individual benefits and risks vary, and for some of these compounds the human evidence is still early.
Dihexa is a newer research compound with limited human data. Reports of cognitive changes, where they exist, generally describe a slower buildup over several weeks rather than an acute effect, and the evidence base is notably thinner than for older nootropic peptides.
Read the full timeline →Drawn from published trial data and how the research community commonly describes this stretch. Not a fixed schedule and not medical advice.
Daily, oral or subcutaneous. For research reference only, not medical advice.
| Phase | Amount |
|---|---|
| Ongoing | 5–20 mg daily (no human data) |
There is no human dosing data. These figures are community lore only.
A rough shopping estimate at the maintenance amount. Your real needs shift with your dose and titration.
| Item | 8-week plan | 12-week plan | 16-week plan |
|---|---|---|---|
| Peptide vials (10 mg) | 45 | 68 | 90 |
| Insulin syringes (U-100) | 56 | 84 | 112 |
| Bacteriostatic water (10 mL) | 9 | 14 | 18 |
| Alcohol swabs (100-count box) | 2 | 2 | 3 |
What a course of Dihexa actually costs, worked from list price and the amount in the schedule above, plus the whole vials a 12-week run would take.
| Supplier | Vial | Price | Per mg | Per dose | 12 weeks | Independent test |
|---|---|---|---|---|---|---|
| BioEdge Research Labs | 5 mg | $129 | $25.80 | $206 | $17,415 (135 vials) | None on file |
One supplier listed so far for this compound.
List prices, checked September 4, 2026. Sale pricing is ignored on purpose so the table does not swing week to week. Verify before ordering.
Suppliers are listed alphabetically. We do not rank them by price, because the cheapest vial and the one worth buying are rarely the same thing. The column that matters is the last one, and today most of it reads "none on file", including for Quartz Peptides, which is owned by this site’s editor. See the disclosure and the COA guide.
Lyophilized: Keep the sealed powder cold and dark, near -20 °C, dry and out of light.
Reconstituted: Refrigerate the mixed vial at 2 to 8 °C and use within about 2 weeks.
Let a cold vial reach room temperature before you open it, so it takes on less condensation.
How strong is the evidence for Dihexa?
We grade it D on a four-point scale. No published human trials. Human safety is unestablished.
What is the half-life of Dihexa?
It is not well characterized in humans. Published pharmacokinetic data for Dihexa is thin, so any specific figure you see quoted should be treated with caution.
What amount of Dihexa is used in the research?
Ongoing: 5–20 mg daily (no human data). There is no human dosing data. These figures are community lore only.
How much does Dihexa cost?
A 5 mg vial lists at $129 from BioEdge Research Labs, which works out to $25.80 per mg and about $206 per dose at the amount used in research. Prices checked September 4, 2026. Price is not a quality signal, so check the certificate of analysis before ordering from anyone.
How is Dihexa stored once reconstituted?
Refrigerate the mixed vial at 2 to 8 °C and use within about 2 weeks.
- McCoy AT, et al. Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents. J Pharmacol Exp Ther. 2013;344:141-154.
- Benoist CC, et al. The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-Met system. J Pharmacol Exp Ther. 2014;351:390-402.