NAD+
Cellular energy and anti-aging coenzyme
Also known as NAD+, the energy coenzyme
- Evidence grade
- CSmall or early human studies onlyScale
- Half-life
- Not well characterized in humans
- Schedule
- A few times weekly, subcutaneous
- Maintenance amount
- 75.00 mg
- Vial sizes sold
- 500 mg, 1000 mg
- Cost per dose
- $8.85
Where a value is not established in people, this table says so rather than filling the box.
A coenzyme at the center of cellular energy production, studied in aging and cellular-repair research. It is handled at high vial volumes.
NAD+ is a coenzyme every cell uses to turn fuel into usable energy and to run repair enzymes like the sirtuins. Levels fall with age, which is why supplying it is studied for cellular energy, repair and healthy aging. It is handled at high vial volumes because the amounts used are large compared with most peptides.
Injectable human data are limited to small pilot studies; the strongest human trials use the oral precursors NR and NMN.
- Injectable NAD+ studied in a small human pilot for changes in the NAD metabolome.
- Oral precursors NR and NMN studied for raising blood NAD+ levels.
- May support cellular energy and redox metabolism.
- Explored for aging and metabolic effects, with human outcome data still thin.
- Intravenous infusion can cause chest tightness, nausea and flushing, often rate-related.
- Injection-site discomfort with subcutaneous or intramuscular use.
- Clinical benefit for injectable NAD+ remains unproven.
- Product purity and sterility vary in unregulated sources.
A summary of the research, not medical advice. Individual benefits and risks vary, and for some of these compounds the human evidence is still early.
NAD+ reports vary sharply by route. Faster infusion or high subcutaneous doses are commonly associated with acute flushing or chest tightness during the dose itself, while energy and cognitive changes are generally reported to build over two to four weeks of regular use.
Read the full timeline →Drawn from published trial data and how the research community commonly describes this stretch. Not a fixed schedule and not medical advice.
Goal of the protocol. Replenish the cellular energy coenzyme tied to metabolism, repair and aging research.
A few times weekly, subcutaneous. For research reference only, not medical advice.
| Phase | Amount |
|---|---|
| Ongoing | 50–100 mg per session |
Reference practice only.
Higher amounts, more injections. As the weekly total climbs, it is commonly divided into two or more injections across the week, which keeps each shot small and easier to tolerate.
A rough shopping estimate at the maintenance amount. Your real needs shift with your dose and titration.
| Item | 12-week plan | 18-week plan | 24-week plan |
|---|---|---|---|
| Peptide vials (500 mg) | 6 | 9 | 11 |
| Insulin syringes (U-100) | 36 | 54 | 72 |
| Bacteriostatic water (10 mL) | 2 | 2 | 3 |
| Alcohol swabs (100-count box) | 1 | 1 | 1 |
What a course of NAD+ actually costs, worked from list price and the amount in the schedule above, plus the whole vials a 12-week run would take.
| Supplier | Vial | Price | Per mg | Per dose | 12 weeks | Independent test |
|---|---|---|---|---|---|---|
| BioEdge Research Labs | 500 mg | $84 | $0.17 | $12.60 | $504 (6 vials) | None on file |
| Quartz Peptides | 500 mg | $59 | $0.12 | $8.85 | $354 (6 vials) | None on file |
List prices, checked September 4, 2026. Sale pricing is ignored on purpose so the table does not swing week to week. Verify before ordering.
Suppliers are listed alphabetically. We do not rank them by price, because the cheapest vial and the one worth buying are rarely the same thing. The column that matters is the last one, and today most of it reads "none on file", including for Quartz Peptides, which is owned by this site’s editor. See the disclosure and the COA guide.
Lyophilized: Keep the sealed powder cool and dark, near -20 °C where possible, dry and out of light.
Reconstituted: Refrigerate the mixed vial at 2 to 8 °C, use within a few weeks and avoid freeze and thaw.
Let a cold vial reach room temperature before you open it, so it takes on less condensation.
How strong is the evidence for NAD+?
We grade it C on a four-point scale. Injectable data is limited to small pilots. The stronger trials use oral NR and NMN.
What is the half-life of NAD+?
It is not well characterized in humans. Published pharmacokinetic data for NAD+ is thin, so any specific figure you see quoted should be treated with caution.
What amount of NAD+ is used in the research?
Ongoing: 50–100 mg per session. Reference practice only.
How much does NAD+ cost?
A 500 mg vial lists at $59 from Quartz Peptides, which works out to $0.12 per mg and about $8.85 per dose at the amount used in research. Prices checked September 4, 2026. Price is not a quality signal, so check the certificate of analysis before ordering from anyone.
How is NAD+ stored once reconstituted?
Refrigerate the mixed vial at 2 to 8 °C, use within a few weeks and avoid freeze and thaw.
- Grant R, et al. A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+. Front Aging Neurosci. 2019;11:257.
- Martens CR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018;9:1286.
